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KMID : 0988920170150020249
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Intestinal Research
2017 Volume.15 No. 2 p.249 ~ p.254
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Crohn’s disease and smoldering multiple myeloma: a case report and literature review
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Park So-Young
Kim Jae-Min
Kang Hyun-Joon
Kim Min-Je
Han Jae-Joon
Maeng Chi-Hoon
Baek Sun-Kyung
Yoon Hwi-Joong
Kim Si-Young
Kim Hyo-Jong
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Abstract
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Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) that presents with abdominal pain, weight loss, and diarrhea. Although the etiology has not been fully elucidated, both environmental and genetic causes are known to be involved. In chronic inflammatory conditions such as IBD, B lymphocytes are chronically stimulated, and they induce monoclonal expansion of plasma cells, sometimes resulting in monoclonal gammopathy of undetermined significance. Immunomodulators that are commonly used to control inflammation, such as tumor necrosis factor-α (TNF-α) blockers could increase the possibility of hematologic malignancy. The pathogenesis of multiple myeloma in association with TNF-α inhibitor therapy is attributed to decreased apoptosis of plasma cell populations. Here, we describe a case of a 36-year-old male patient who was diagnosed with immunoglobulin A subtype smoldering multiple myeloma during the treatment for CD with infliximab and adalimumab. We report this case along with a review of the literature on cases of multiple myeloma that occurred in conjunction with CD.
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KEYWORD
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Crohn disease, Multiple myeloma, Tumor necrosis factor-alpha
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